Nature, 1988, Vol.332(6162), p.378
The interaction between helper T cells and B cells, leading to the production of antibody to thymus-dependent antigens, was the first cell interaction clearly defined in the immune system; it remains both paradigmatic and controversial. Two requirements of this interaction, that the helper cell (TH) and the B cell must recognize antigenic determinants that are physically linked, and that the TH and the B cell must share genes encoding major histocompatibility complex (MHC) class II molecules, led to the concept that TH-B interaction required an intimate physical association of the two cell types. But in vitro studies have shown that TH can be replaced by soluble, antigen-nonspecific factors, capable of activating any B cell to secrete antibody. We have previously proposed that the requirements for TH-B contact might result from TH cells releasing their lymphokines in a polar fashion directed at that portion of the cell membrane where T-cell receptor cross-linking is actually occurring....
Animals–Physiology ; Antigen-Presenting Cells–Secretion ; Cell Compartmentation–Physiology ; Cells, Cultured–Secretion ; Exocytosis–Ultrastructure ; Lymphocyte Cooperation–Ultrastructure ; Lymphokines–Ultrastructure ; Mice–Ultrastructure ; Mice, Inbred Akr–Ultrastructure ; Receptors, Antigen, T-Cell–Ultrastructure ; T-Lymphocytes, Helper-Inducer–Ultrastructure ; T-Lymphocytes, Helper-Inducer–Ultrastructure ; Medical Research ; Cellular Biology ; Lymphokines ; Receptors, Antigen, T-Cell;
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