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  • 1
    Language: English
    In: Leukemia, 2014-08, Vol.28 (8), p.1596-1605
    Description: As significant numbers of acute myeloid leukemia (AML) patients are still refractory to conventional therapies or experience relapse, immunotherapy using T cells expressing chimeric antigen receptors (CARs) might represent a valid treatment option. AML cells frequently overexpress the myeloid antigens CD33 and CD123, for which specific CARs can be generated. However, CD33 is also expressed on normal hematopoietic stem/progenitor cells (HSPCs), and its targeting could potentially impair normal hematopoiesis. In contrast, CD123 is widely expressed by AML, while low expression is detected on HSPCs, making it a much more attractive target. In this study we describe the in vivo efficacy and safety of using cytokine-induced killer (CIK) cells genetically modified to express anti-CD33 or anti-CD123 CAR to target AML. We show that both these modified T cells are very efficient in reducing leukemia burden in vivo, but only the anti-CD123 CAR has limited killing on normal HSPCs, thus making it a very attractive immunotherapeutic tool for AML treatment.
    Subject(s): Animals ; Humans ; Recombinant Fusion Proteins - therapeutic use ; Sialic Acid Binding Ig-like Lectin 3 - antagonists & inhibitors ; Cell Line, Tumor ; T-Lymphocytes - immunology ; Mice ; Mice, SCID ; Leukemia, Myeloid, Acute - therapy ; Receptors, Antigen - therapeutic use ; Cytokine-Induced Killer Cells - immunology ; Interleukin-3 Receptor alpha Subunit - antagonists & inhibitors ; Properties ; Cell receptors ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: BioControl (Dordrecht, Netherlands), 2014-04, Vol.59 (2), p.175-183
    Description: The omnivorous predators Nesidiocoris tenuis (Reuter) and Macrolophus pygmaeus Rambur (Hemiptera: Miridae) are indigenous natural enemies that commonly inhabit tomato crops in the Mediterranean basin. Both predators are mass-reared and primarily released to control whiteflies, although recently they have also contributed to the control of the invasive tomato pest Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae). The life history traits of these two predators have been studied in the laboratory under the conditions of being fed exclusively the eggs of T. absoluta or the eggs of the factitious prey Ephestia kuehniella (Zeller) (Lepidoptera: Pyralidae). Immature stages of both predator species successfully developed while preying on eggs of T. absoluta. However, the mature M. pygmaeus females produced significantly lower numbers of offspring in comparison to the offspring produced when preying on E. kuehniella eggs. This resulted in higher than expected demographic indexes for N. tenuis when compared to M. pygmaeus (e.g., the intrinsic rates of increase were 0.127 and 0.005, respectively). Our results support previous studies on the potential of N. tenuis has as biological control agent of T. absoluta, and indicate that the role of M. pygmaeus in controlling T. absoluta in the absence of other food sources is possibly limited.
    Subject(s): Entomology ; Animal Biochemistry ; Behavioural Sciences ; Tomato ; Life Sciences ; Plant Pathology ; Macrolophus pygmaeus ; Nesidiocoris tenuis ; Invasive pest ; Development time ; Agriculture ; Animal Ecology ; Intrinsic rate of increase ; Biological control ; Agricultural industry ; Aleyrodidae ; Tomatoes ; Pests ; Comparative analysis ; Agricultural pests
    ISSN: 1386-6141
    E-ISSN: 1573-8248
    Source: Alma/SFX Local Collection
    Source: ProQuest Central
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  • 3
    Language: English
    In: Leukemia, 2015-01, Vol.29 (1), p.1-10
    Description: When treatment fails, the clinical outcome of acute leukemia patients is usually very poor, particularly when failure occurs after transplantation. A second allogeneic stem cell transplant could be envisaged as an effective and feasible salvage option in younger patients having a late relapse and an available donor. Unmanipulated or minimally manipulated donor T cells may also be effective in a minority of patients but the main limit remains the induction of severe graft-versus-host disease. This clinical complication has brought about a huge research effort that led to the development of leukemia-specific T-cell therapy aiming at the direct recognition of leukemia-specific rather than minor histocompatibility antigens. Despite a great scientific interest, the clinical feasibility of such an approach has proven to be quite problematic. To overcome this limitation, more research has moved toward the choice of targeting commonly expressed hematopoietic specific antigens by the genetic modification of unselected T cells. The best example of this is represented by the anti-CD19 chimeric antigen receptor (CD19.CAR) T cells. As a possible alternative to the genetic manipulation of unselected T cells, specific T-cell subpopulations with in vivo favorable homing and long-term survival properties have been genetically modified by CAR molecules. Finally, the use of naturally cytotoxic effector cells such as natural killer and cytokine-induced killer cells has been proposed in several clinical trials. The clinical development of these latter cells could also be further expanded by additional genetic modifications using the CAR technology.
    Subject(s): Cell Line ; Recurrence ; Leukemia - pathology ; Humans ; Middle Aged ; Child, Preschool ; Leukemia - therapy ; Infant ; Feasibility Studies ; Young Adult ; Immunotherapy ; Adolescent ; Aged, 80 and over ; Adult ; Immunologic Memory ; T-Lymphocytes - immunology ; Aged ; Child ; Prevention ; Care and treatment ; Relapse ; Leukemia ; Patient outcomes ; Transplantation ; Methods ; Hematopoietic stem cells ; Diseases ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Journal of Economic Entomology, 2015, Vol.108 (3), p.1191-1197
    Description: ABSTRACT Insect-proof nets are thought to be effective physical barriers to protect tomato crops against several insect pests, including the invasive tomato pest, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae). However, protected tomato crops are frequently infested by this destructive pest, and there is a higher infestation of plants closer to openings in Mediterranean greenhouses, suggesting that immigrating adults can easily walk on these protective materials and find a way to reach the crop. Laboratory bioassays were carried out to characterize the potential toxicity of α-cypermethrin-treated insect-proof nets (Agronet) against T. absoluta adults. The data showed that the net acts mainly through a variety of chronic sublethal effects rather than acute ones. Reduced longevity and, more markedly, a reduced number of laid eggs were observed after the moths were exposed to the treated net over the duration of their lifetimes. A Y-tube experiment showed that the treated net does not affect the T. absol...
    Subject(s): olfaction ; invasive pest ; sublethal effect ; pyrethroid ; IPM ; Animals ; Insect Repellents ; Insecticide-Treated Bednets ; Pyrethrins ; Moths - physiology ; Female ; Insecticides ; Male ; Olfactory Perception ; Insect Control - methods ; Laboratories ; Toxicity ; Crops ; Bioassays ; Greenhouses ; Pests ; Host location ; Eggs ; Invasive species ; Nets ; Insects ; Sublethal effects ; Cypermethrin ; Barriers ; Olfaction ; Butterflies & moths ; Adults ; Tomatoes ; Infestation ; Index Medicus ; Life Sciences ; Environmental Sciences
    ISSN: 0022-0493
    E-ISSN: 1938-291X
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: British journal of surgery, 2018-10, Vol.105 (11), p.1487-1492
    Description: Background Ideal surgical treatment for acute duodenal injuries should offer a definitive treatment, with low morbidity and mortality. It should be simple and easily reproducible by acute care surgeons in an emergency. Duodenal injury, due to major perforated or bleeding peptic ulcers or iatrogenic/traumatic perforation, represents a surgical challenge, with high morbidity and mortality. The aim was to review definitive surgery with pancreas‐sparing, ampulla‐preserving duodenectomy for these patients. Methods Pancreas‐sparing, ampulla‐preserving D1–D2 duodenectomy was used for patients presenting with major duodenal injuries over a 5‐year interval. The ampulla was identified and preserved using a transcystic/transpapillary tube. The outcomes were recorded. Results Ten patients were treated with this technique; seven had perforated or bleeding peptic ulcers, two had iatrogenic perforations and one blunt abdominal trauma. Their mean age was 78 (range 65–84) years. Four patients were haemodynamically unstable. The location of the duodenal injury was always D1 and/or D2, above or in close proximity to the ampulla of Vater. The surgical approach was open in nine patients and laparoscopic in one. The mean duration of surgery was 264 (range 170–377) min. All patients were transferred to the ICU after surgery (mean ICU stay 4·4 (range 1–11) days), and the overall mean hospital stay was 17·8 (range 10–32) days. Six patients developed major postoperative complications: cardiorespiratory failure in five and gastrointestinal complications in four. Surgical reoperation was needed in one patient for postoperative necrotizing and bleeding pancreatitis. Two patients died from their complications. Conclusion Pancreas‐sparing, ampulla‐preserving D1–D2 duodenectomy for emergency treatment of major duodenal perforations is feasible and associated with satisfactory outcomes. Useful option
    Subject(s): Follow-Up Studies ; Humans ; Rupture ; Male ; Treatment Outcome ; Intestinal Perforation - diagnosis ; Intestinal Perforation - surgery ; Pancreas - surgery ; Pancreaticoduodenectomy - methods ; Duodenum - injuries ; Organ Sparing Treatments - methods ; Duodenoscopy ; Duodenum - surgery ; Time Factors ; Aged, 80 and over ; Ampulla of Vater - surgery ; Female ; Aged ; Duodenum - diagnostic imaging ; Pancreas ; Surgery ; Mortality ; Ulcers ; Injuries ; Index Medicus ; Abridged Index Medicus
    ISSN: 0007-1323
    E-ISSN: 1365-2168
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Advances in civil engineering, 2020-05-23, Vol.2020, p.1-6
    Description: Anti-slide pile is one of the most frequently used measures in landslide control globally. Pile-spacing has always been determined by the load capacity of single piles or according to engineering empirical experience. Many engineering practices and laboratory experiments show that the soil arching effect exists in landslide control with anti-slide piles. In this study, we aim to calculate pile-spacing in terms of the soil arching effect. We investigated the pile-soil interaction mechanism and propose that, at the limit, the pile-back soil arch resists landslide thrust only. According to Mohr–Coulomb strength theory and limit equilibrium theories, we derived a new pile-spacing calculation equation. We verified the derived pile-spacing calculation equation with real projects. The calculated results are similar to those of practical engineering designs, in which the difference is within 10%. The equation can be used in anti-slide pile preliminary design. This study can be a reference for pile-spacing calculation based on the soil arching effect.
    ISSN: 1687-8086
    E-ISSN: 1687-8094
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: European radiology, 2013-10, Vol.23 (10), p.2838-2845
    Description: To evaluate the safety and efficacy of a new liquid embolic agent in brain arteriovenous malformation (bAVMs) embolisation.A prospective, multicentre series was conducted at 11 interventional centres in Europe to evaluate embolisation of bAVMs with the new liquid embolic agent. Technical conditions, complications, clinical outcome and anatomical results were independently analysed.From December 2005 to December 2008, 117 patients (72 male; 45 female, aged 18–75 years) were included. Clinical presentation was mostly haemorrhage (34.2 %) and seizures (28.2 %). Most AVMs were located in the brain hemispheres (85.5 %). AVMs were 〈3 cm in 52.1 % of patients and ≥3 cm in 47.9 %. Morbidity was observed in 6/117 patients (5.1 %), related to haemorrhagic events in 2 cases and non-haemorrhagic complications in 4 cases. Five patients (4.3 %) died in relation to the treatment (bleeding in 4 patients and extensive venous thrombosis in 1). Complete occlusion of the AVM by embolisation alone was obtained in 23.5 % of patients. Complementary treatment was performed in 82.3 % of patients with partial AVM occlusion, mostly radiosurgery.In this prospective, multicentre, European, observational series, the new liquid embolic agent proved to be suitable for BAVM embolisation, with acceptable morbidity and mortality and good efficacy.• Numerous interventional techniques have been used to embolise brain arteriovenous malformations (AVMs). • This prospective multicentre study demonstrates the suitability of a liquid embolic agent. • The safety of treatment using Onyx is acceptable. • Such embolisation leads to complete AVM occlusion in 23.5 % of patients.
    Subject(s): Diagnostic Radiology ; Endovascular treatment ; Radiosurgery ; Internal Medicine ; Brain arteriovenous malformations ; Neuroradiology ; Medicine & Public Health ; Surgical treatment ; Embolisation ; Interventional Radiology ; Onyx ; Imaging / Radiology ; Ultrasound ; Embolization, Therapeutic - statistics & numerical data ; Prevalence ; Prospective Studies ; Humans ; Middle Aged ; Male ; Young Adult ; Aged, 80 and over ; Adult ; Female ; Intracranial Arteriovenous Malformations - therapy ; Embolization, Therapeutic - methods ; Arteriovenous Fistula - epidemiology ; Dimethyl Sulfoxide - therapeutic use ; Intracranial Arteriovenous Malformations - diagnostic imaging ; Arteriovenous Fistula - diagnostic imaging ; Arteriovenous Fistula - therapy ; Risk Factors ; Europe - epidemiology ; Polyvinyls - therapeutic use ; Treatment Outcome ; Radiography ; Intracranial Arteriovenous Malformations - epidemiology ; Adolescent ; Aged ; Hemostatics - therapeutic use ; Brain ; Index Medicus
    ISSN: 0938-7994
    E-ISSN: 1432-1084
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: Leukemia, 2010-03, Vol.24 (3), p.521-535
    Description: Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value for predicting outcome and the possibilities for implementation of MRD diagnostics in treatment stratification. Therefore, there is an increasing need for standardization of methodologies and harmonization of terminology. For this purpose, a panel of representatives of all major European study groups on childhood and adult ALL and of international experts on PCR- and flow cytometry-based MRD assessment was built in the context of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. The panel summarized the current state of MRD diagnostics in ALL and developed recommendations on the minimal technical requirements that should be fulfilled before implementation of MRD diagnostics into clinical trials. Finally, a common terminology for a standard description of MRD response and monitoring was established defining the terms 'complete MRD response', 'MRD persistence' and 'MRD reappearance'. The proposed MRD terminology may allow a refined and standardized assessment of response to treatment in adult and childhood ALL, and provides a sound basis for the comparison of MRD results between different treatment protocols.
    Subject(s): Hematologic and hematopoietic diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Biological and medical sciences ; Medical sciences ; Genes, Immunoglobulin ; Fusion Proteins, bcr-abl - genetics ; Flow Cytometry ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Gene Rearrangement ; Humans ; Neoplasm, Residual - diagnosis ; Polymerase Chain Reaction ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Care and treatment ; Relapse ; Patient outcomes ; Genetic aspects ; Acute lymphocytic leukemia ; Research ; Diagnosis ; Risk factors ; Cancer ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Leukemia, 2008-04, Vol.22 (4), p.771-782
    Description: Detection of minimal residual disease (MRD) is the most sensitive method to evaluate treatment response and one of the strongest predictors of outcome in childhood acute lymphoblastic leukemia (ALL). The 10-year update on the I-BFM-SG MRD study 91 demonstrates stable results (event-free survival), that is, standard risk group (MRD-SR) 93%, intermediate risk group (MRD-IR) 74%, and high risk group (MRD-HR) 16%. In multicenter trial AIEOP-BFM ALL 2000, patients were stratified by MRD detection using quantitative PCR after induction (TP1) and consolidation treatment (TP2). From 1 July 2000 to 31 October 2004, PCR target identification was performed in 3341 patients: 2365 (71%) patients had two or more sensitive targets (〈 or =10(-4)), 671 (20%) patients revealed only one sensitive target, 217 (6%) patients had targets with lower sensitivity, and 88 (3%) patients had no targets. MRD-based risk group assignment was feasible in 2594 (78%) patients: 40% were classified as MRD-SR (two sensitive targets, MRD negativity at both time points), 8% as MRD-HR (MRD 〉 or =10(-3) at TP2), and 52% as MRD-IR. The remaining 823 patients were stratified according to clinical risk features: HR (n=108) and IR (n=715). In conclusion, MRD-PCR-based stratification using stringent criteria is feasible in almost 80% of patients in an international multicenter trial.
    Subject(s): Hematologic and hematopoietic diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Biological and medical sciences ; Medical sciences ; Genes, Immunoglobulin - genetics ; Risk Assessment ; Gene Rearrangement, T-Lymphocyte ; Humans ; Child, Preschool ; Infant ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Neoplasm, Residual ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Gene Rearrangement ; Adolescent ; Polymerase Chain Reaction ; Child ; Polymerase chain reaction ; Care and treatment ; Usage ; Antigen receptors, T cell ; Receptors ; Genetic aspects ; Acute lymphocytic leukemia ; Diagnosis ; Research ; T cells ; Health aspects ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: Scientific reports, 2020-07-30, Vol.10 (1), p.12892-12892
    Description: Children and adolescents with haematological malignancies (PedHM) are characterized by a severe loss of exercise ability during cancer treatment, lasting throughout their lives once healed and impacting their social inclusion prospects. The investigation of the effect of a precision-based exercise program on the connections between systems of the body in PedHM patients is the new frontier in clinical exercise physiology. This study is aimed at evaluating the effects of 11 weeks (3 times weekly) of combined training (cardiorespiratory, resistance, balance and flexibility) on the exercise intolerance in PedHM patients. Two-hundred twenty-six PedHM patients were recruited (47% F). High or medium frequency participation (HAd and MAd) was considered when a participant joined; 〉 65% or between 30% and 〈 64% of training sessions, respectively. The "up and down stairs'' test (TUDS), "6 min walking" test (6MWT), the "5 Repetition Maximum strength" leg extension and arm lateral raise test (5RM-LE and 5RM-ALR), flexibility (stand and reach), and balance (stabilometry), were performed and evaluated before and after training. The TUDS, the 5RM-LE and 5RM-ALR, and the flexibility exercises showed an increase in HAd and MAd groups (P 〈 0.05), while the 6MWT and balance tests showed improvement only in HAd group (P 〈 0.0001). These results support the ever-growing theory that, in the case of the treatment of PedHM, 'exercise is medicine' and it has the potential to increase the patient's chances of social inclusion.
    Subject(s): Hematologic Neoplasms - therapy ; Humans ; Child, Preschool ; Male ; Exercise Therapy ; Adolescent ; Adult ; Female ; Physical Fitness ; Child ; Hematologic Neoplasms - physiopathology ; Muscle Strength ; Postural Balance ; Precision Medicine ; Walking ; Intolerance ; Hematology ; Children ; Adolescents ; Arm ; Patients ; Flexibility ; Index Medicus
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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