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  • 1
    Language: English
    In: Human molecular genetics, 2008-10-01, Vol.17 (19), p.2967-2977
    Description: Diarrhea predominant irritable bowel syndrome (IBS-D) is a complex disorder related to dysfunctions in the serotonergic system. As cis-regulatory variants can play a role in the etiology of complex conditions, we investigated the untranslated regions (UTRs) of the serotonin receptor type 3 subunit genes HTR3A and HTR3E. Mutation analysis was carried out in a pilot sample of 200 IBS patients and 100 healthy controls from the UK. The novel HTR3E 3′-UTR variant c.*76G〉A (rs62625044) was associated with female IBS-D (P = 0.033, OR = 8.53). This association was confirmed in a replication study, including 119 IBS-D patients and 195 controls from Germany (P = 0.0046, OR = 4.92). Pooled analysis resulted in a highly significant association of c.*76G〉A with female IBS-D (P = 0.0002, OR = 5.39). In a reporter assay, c.*76G〉A affected binding of miR-510 to the HTR3E 3′-UTR and caused elevated luciferase expression. HTR3E and miR-510 co-localize in enterocytes of the gut epithelium as shown by in situ hybridization and RT-PCR. This is the first example indicating micro RNA-related expression regulation of a serotonin receptor gene with a cis-regulatory variant affecting this regulation and appearing to be associated with female IBS-D.
    Subject(s): Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Biological and medical sciences ; Molecular and cellular biology ; Genetics of eukaryotes. Biological and molecular evolution ; Medical sciences ; Other diseases. Semiology ; Species Specificity ; Humans ; Middle Aged ; 3' Untranslated Regions - genetics ; Male ; Receptors, Serotonin - genetics ; Case-Control Studies ; Adult ; Female ; Cell Line ; Intestinal Mucosa ; Gene Expression ; Irritable Bowel Syndrome - metabolism ; United Kingdom ; Irritable Bowel Syndrome - genetics ; Receptors, Serotonin - metabolism ; Receptors, Serotonin, 5-HT3 ; Diarrhea - genetics ; Adolescent ; Diarrhea - metabolism ; Aged ; MicroRNAs - genetics ; Mutation ; Germany ; Cohort Studies ; Index Medicus
    ISSN: 0964-6906
    E-ISSN: 1460-2083
    Source: Oxford Journals 2016 Current and Archive A-Z Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 2
    Language: English
    In: BMC cancer, 2020-04-28, Vol.20 (1), p.355-355
    Description: This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome of multiple tumor entities, the effect of the specific number of multidisciplinary tumor boards and potential differences between the tumor entities. By a matched-pair analysis we compared the response to treatment, overall survival, relapse or disease free survival and progression free survival of patients whose cases were discussed in a tumor board meeting with patients whose cases were not. It was performed with patients registered in the cancer registry of the University of Bonn and diagnosed between 2010 and 2016. After the matching process with a pool of 7262 patients a total of 454 patients with 66 different tumor types were included in this study. First, patients with three or more multidisciplinary tumor board meetings in their history show a significantly better overall survival than patients with no tumor board meeting. Second, response to treatment, relapse free survival and time to progression were not found to be significantly different. Third, there was no significant difference for a specific tumor entity. This study revealed a positive impact of a higher number of multidisciplinary tumor boards on the clinical outcome. Also, our analysis hints towards a positive effect of multidisciplinary tumor boards on overall survival.
    Subject(s): Prognosis ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Recurrence, Local - therapy ; Neoplasms - mortality ; Male ; Survival Rate ; Combined Modality Therapy ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Young Adult ; Interdisciplinary Communication ; Neoplasms - therapy ; Patient Care Team - organization & administration ; Aged, 80 and over ; Adult ; Female ; Aged ; Retrospective Studies ; Neoplasms - pathology ; Index Medicus ; Time to progression ; Relapse free survival ; Multidisciplinary tumor board ; Matched pair analysis ; Overall survival ; Cancer
    ISSN: 1471-2407
    E-ISSN: 1471-2407
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 3
    Language: English
    In: BMC cancer, 2019-10-30, Vol.19 (1), p.1024-1024
    Description: Research shows disparities in cancer outcomes by ethnicity or socio-economic status. Therefore, it is the aim of our study to perform a matched-pair analysis which compares the outcome of German and non-German (in the following described as 'foreign') cancer patients being treated at the Center for Integrated Oncology (CIO) Köln Bonn at the University Hospital of Bonn between January 2010 and June 2016. During this time, 6314 well-documented patients received a diagnosis of cancer. Out of these patients, 219 patients with foreign nationality could be matched to German patients based on diagnostic and demographic criteria and were included in the study. All of these 438 patients were well characterized concerning survival data (Overall survival, Progression-free survival and Time to progression) and response to treatment. No significant differences regarding the patients' survival and response rates were seen when all German and foreign patients were compared. A subgroup analysis of German and foreign patients with head and neck cancer revealed a significantly longer progression-free survival for the German patients. Differences in response to treatment could not be found in this subgroup analysis. In summary, no major differences in survival and response rates of German and foreign cancer patients were revealed in this study. Nevertheless, the differences in progression-free survival, which could be found in the subgroup analysis of patients with head and neck cancer, should lead to further research, especially evaluating the role of infectious diseases like human papillomavirus (HPV) and Epstein-Barr virus (EBV) on carcinogenesis and disease progression.
    Subject(s): Follow-Up Studies ; Humans ; Middle Aged ; Head and Neck Neoplasms - therapy ; Kaplan-Meier Estimate ; European Continental Ancestry Group ; Male ; Young Adult ; Genital Neoplasms, Female - mortality ; Genital Neoplasms, Female - ethnology ; Genital Neoplasms, Female - therapy ; Matched-Pair Analysis ; Progression-Free Survival ; Germany - ethnology ; Head and Neck Neoplasms - ethnology ; Aged, 80 and over ; Adult ; Female ; Aged ; Retrospective Studies ; Head and Neck Neoplasms - mortality ; Social classes ; Care and treatment ; Diagnosis ; Analysis ; Cancer ; Index Medicus ; Migrants ; Matched pair analysis ; Survival ; Inequalities
    ISSN: 1471-2407
    E-ISSN: 1471-2407
    Source: BioMedCentral Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Breast cancer research and treatment, 2008-02, Vol.107 (3), p.331-335
    Description: Lobular carcinoma in situ (LCIS) of the breast is generally considered an indicator for a bilaterally increased risk of invasive breast cancer (IBC). However, as recent studies suggested a clonal relationship between a subset of synchronous LCIS and invasive lobular carcinomas (ILC), we aimed to examine a possible precursor role for LCIS and IBC occurring in the same breast at a later time. Out of a consecutive series of 88 LCIS, nine patients developed IBC (5 ILC and 4 invasive ductal carcinomas) between 2 and 10 years after initial biopsy. For each case, mitochondrial DNA heteroplasmy was analyzed in normal mammary gland epithelia, LCIS and IBC by PCR, direct DNA sequencing and phylogenetic tree clustering. Two cases of LCIS and ILC showed identical patterns of heteroplasmy. In one further case, additional mtDNA mutations were present in the ILC following LCIS. The remaining two cases of ILC and all 4 IDC were clonally unrelated to the previously diagnosed LCIS. While the overall risk for the development of invasive breast cancer following LCIS is relatively low and the majority of cases are clonally unrelated, our data clearly show that some LCIS eventually do progress to ILC. Thus, LCIS represents both an indicator lesion for an increased risk of subsequent invasive breast cancer and in some cases a precursor of ILC.
    Subject(s): Clonality ; Oncology ; Breast cancer ; Mitochondrial DNA heteroplasmy ; Medicine & Public Health ; Lobular carcinoma in situ (LCIS) ; Gynecology. Andrology. Obstetrics ; Mammary gland diseases ; Biological and medical sciences ; Medical sciences ; Tumors ; Carcinoma, Lobular - pathology ; Carcinoma in Situ - pathology ; Humans ; Middle Aged ; Cadherins - analysis ; Breast Neoplasms - genetics ; Carcinoma in Situ - genetics ; DNA, Mitochondrial - genetics ; Carcinoma, Lobular - genetics ; Breast Neoplasms - pathology ; Adult ; Female ; Mutation ; Neoplasms, Second Primary - genetics ; Neoplasms, Second Primary - pathology ; Index Medicus
    ISSN: 0167-6806
    E-ISSN: 1573-7217
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: Neoplasia (New York, N.Y.), 2008-10, Vol.10 (10), p.1049,IN1-1056,IN2
    Description: BACKGROUND: Decoy receptor 3 (DcR3) is a soluble protein that binds to and inactivates the death ligand CD95L. Here, we studied a possible association between DcR3 expression and prognosis in patients with renal cell carcinomas (RCCs). METHODS: A tissue microarray containing RCC tumor tissue samples and corresponding normal tissue samples was generated. Decoy receptor 3 expression in tumors of 560 patients was examined by immunohistochemistry. The effect of DcR3 expression on disease-specific survival and progression-free survival was assessed using univariate analysis and multivariate Cox regression analysis. Decoy receptor 3 serum levels were determined by ELISA. FINDINGS: High DcR3 expression was associated with high-grade (P = .005) and high-stage (P = .048) RCCs. The incidence of distant metastasis (P = .03) and lymph node metastasis (P = .002) was significantly higher in the group with high DcR3 expression. Decoy receptor 3 expression correlated negatively with disease-specific survival (P 〈 .001) and progression-free survival (P 〈 .001) in univariate analyses. A multivariate Cox regression analysis retained DcR3 expression as an independent prognostic factor that outperformed the Karnofsky performance status. In patients with high-stage RCCs expressing DcR3, the 2-year survival probability was 25%, whereas in patients with DcR3-negative tumors, the survival probability was 65% (P 〈 .001). Moreover, DcR3 serum levels were significantly higher in patients with high-stage localized disease (P = .007) and metastatic disease (P = .001). INTERPRETATION: DcR3 expression is an independent prognostic factor of RCC progression and mortality. Therefore, the assessment of DcR3 expression levels offers valuable prognostic information that could be used to select patients for adjuvant therapy studies.
    Subject(s): Kidney Neoplasms - genetics ; Prognosis ; Receptors, Tumor Necrosis Factor, Member 6b - metabolism ; Tissue Array Analysis ; Humans ; Middle Aged ; Carcinoma, Renal Cell - genetics ; Male ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - diagnosis ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Adult ; Female ; Receptors, Tumor Necrosis Factor, Member 6b - genetics ; Carcinoma, Renal Cell - pathology ; Receptors, Tumor Necrosis Factor, Member 6b - physiology ; In Situ Hybridization, Fluorescence ; Biomarkers, Tumor - physiology ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - diagnosis ; Kidney Neoplasms - pathology ; Aged ; Biomarkers, Tumor - genetics ; Cohort Studies ; Index Medicus
    ISSN: 1476-5586
    E-ISSN: 1476-5586
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 6
    Language: English
    In: Molecular cancer research, 2007-12-01, Vol.5 (12), p.1232-1240
    Description: Glioblastomas, the most malignant of all brain tumors, are characterized by cellular resistance to apoptosis and a highly invasive growth pattern. These factors contribute to the poor response of glioblastomas to radiochemotherapy and prevent their complete neurosurgical resection. However, the driving force behind the distinct motility of glioma cells is only partly understood. Here, we report that in the absence of cellular stress and proapoptotic stimuli, human glioblastoma cells exhibit a constitutive activation of caspases in vivo and in vitro . The inhibition of caspases by various peptide inhibitors decreases the migration of cells in scrape motility assays and the invasiveness of cells in spheroid assays. Similarly, specific small interfering RNA– or antisense-mediated down-regulation of caspase-3 and caspase-8 results in an inhibition of the migratory potential of glioma cells. The constitutive caspase-dependent motility of glioblastoma cells is independent of CD95 activation and it is not mediated by mitogen-activated protein/extracellular signal-regulated kinase kinase signaling. The basal caspase activity is accompanied by a constant cleavage of the motility-associated gelsolin protein, which may contribute to the caspase-mediated promotion of migration and invasiveness in glioblastoma cells. Our results suggest that the administration of low doses of caspase inhibitors that block glioma cell motility without affecting the execution of apoptotic cell death may be exploited as a novel strategy for the treatment of glioblastomas. (Mol Cancer Res 2007;5(12):1232–40)
    Subject(s): migration ; apoptosis ; brain tumors ; invasion ; gliomas ; caspases ; Brain Neoplasms - enzymology ; Glioblastoma - enzymology ; MAP Kinase Signaling System - physiology ; Gelsolin - metabolism ; Neoplasm Invasiveness ; Humans ; Brain Neoplasms - pathology ; Caspase 3 - metabolism ; Caspase 8 - metabolism ; Enzyme Inhibitors - pharmacology ; fas Receptor - metabolism ; Caspase Inhibitors ; Cell Movement - physiology ; Caspase 8 - genetics ; Glioblastoma - pathology ; Caspase 3 - genetics ; Cell Line, Tumor ; RNA, Small Interfering ; Index Medicus
    ISSN: 1541-7786
    E-ISSN: 1557-3125
    Source: HighWire Press (Free Journals)
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Language: English
    In: Virchows Archiv : an international journal of pathology, 2007-06, Vol.450 (6), p.713-717
    Description: The vascular type of Ehlers-Danlos syndrome (type IV) is an infrequent disease caused by heterozygous germline mutations in the procollagen 3A gene (COL3A1). Clinical signs include characteristic facial features, easy bruising, and a translucent skin. These signs are less obvious than the hyperflexibility of skin and joints seen in other types of Ehlers-Danlos syndrome. Therefore, diagnosis of Ehlers-Danlos syndrome type IV is usually not considered until complications have occurred. Complications include spontaneous ruptures of vessels and hollow organs, particularly the colon. We, herein, report pathologic findings in colon specimens from related Ehlers-Danlos syndrome type IV patients. Thorough examination revealed abnormalities of the large bowel architecture including abrupt changes in the caliber of the lamina muscularis, secondary diverticula formation, and strongly reduced expression of abnormal collagen 3. These findings are not seen in other diseases of the colon and should prompt the pathologist to include Ehlers-Danlos syndrome type IV in the differential diagnosis of spontaneous bowel perforation in younger patients.
    Subject(s): Pathology ; COL3A1 ; Large bowel perforation ; Medicine & Public Health ; Vascular type ; Ehlers-Danlos syndrome type IV ; Biological and medical sciences ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Immunohistochemistry ; Diagnosis, Differential ; Ehlers-Danlos Syndrome - classification ; Colon - pathology ; Humans ; Collagen Type III - metabolism ; Male ; Colonic Diseases - etiology ; Microscopy, Electron ; Intestinal Perforation - diagnosis ; Colon - metabolism ; Colonic Diseases - pathology ; Ehlers-Danlos Syndrome - complications ; Ehlers-Danlos Syndrome - pathology ; Diverticulum - pathology ; Ehlers-Danlos Syndrome - metabolism ; Adult ; Female ; Diverticulum - etiology ; Index Medicus
    ISSN: 0945-6317
    E-ISSN: 1432-2307
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: International journal of colorectal disease, 2011-08, Vol.26 (8), p.989-998
    Description: There is increasing evidence that a defect of the gastrointestinal mucosal barrier is important for the development of inflammatory bowel diseases (IBD). The hydrophobicity of the colonic mucosal surface is a measure of its resistance to luminal antigens, e.g. of bacterial origin. Therefore, the purpose of this study was to determine this parameter in patients suffering from IBD.Nineteen patients with ulcerative colitis (UC), ten patients with Crohn’s disease (CD) and 20 controls were examined. All underwent colonic surgery at the University Hospital Heidelberg. Clinical disease activity was determined. From every subject, colonic tissue specimens were obtained, and hydrophobicity of the mucosal surface was determined with a goniometer by multiple plateau contact angle measurements. Histological evaluation of disease activity was performed in directly adjacent tissue specimens.Hydrophobicity of the colonic mucosal surface, expressed as plateau contact angles, was significantly reduced in patients with UC (mean ± SEM, 47.8° ± 3.4°) compared to those with CD (72.0° ± 5.2°) and controls (72.5° ± 5.6°; over-all P = 0.0004; UC versus controls, P 〈 0.001; UC versus CD, P 〈 0.05; CD versus controls, P 〉 0.05). Between mucosal hydrophobicity and clinical disease activity, as well as mucosal hydrophobicity and histological disease activity, no significant correlation was found.The results suggest a defective physicochemical barrier as an essential factor in the pathogenesis of UC, but not CD. The fact that no correlation was found between mucosal hydrophobicity and disease activity may indicate that the loss of mucosal hydrophobicity in UC is not exclusively a secondary effect due to inflammation.
    Subject(s): Medicine & Public Health ; Surgery ; Hepatology ; Mucosal barrier ; Gastroenterology ; Phosphatidylcholine ; Internal Medicine ; Hydrophobicity ; Proctology ; Ulcerative colitis ; Crohn’s disease ; Gastroenterology. Liver. Pancreas. Abdomen ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Biological and medical sciences ; Medical sciences ; Other diseases. Semiology ; Colon - pathology ; Humans ; Middle Aged ; Male ; Colitis, Ulcerative - pathology ; Case-Control Studies ; Young Adult ; Crohn Disease - pathology ; Surface Properties ; Adolescent ; Hydrophobic and Hydrophilic Interactions ; Adult ; Female ; Aged ; Intestinal Mucosa - pathology ; Antigens ; Development and progression ; Crohn's disease ; Index Medicus
    ISSN: 0179-1958
    E-ISSN: 1432-1262
    Source: Springer Online Journal Archives (DFG Nationallizenzen)
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 9
    Language: English
    In: Journal of Virology, 2005-04-15, Vol.79 (8), p.5220-5226
    Description: Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
    Subject(s): Fundamental and applied biological sciences. Psychology ; Miscellaneous ; Infectious diseases ; Microbiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Biological and medical sciences ; Medical sciences ; Human viral diseases ; Virology ; Antigens, CD - analysis ; Microscopy, Confocal ; Monocytes - virology ; HIV-1 - growth & development ; Macrophages - virology ; HIV-1 - isolation & purification ; Humans ; Cells, Cultured ; Macrophages - immunology ; HIV-1 - classification ; Index Medicus ; Pathogenesis and Immunity
    ISSN: 0022-538X
    E-ISSN: 1098-5514
    Source: HighWire Press (Free Journals)
    Source: Hellenic Academic Libraries Link
    Source: PubMed Central
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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  • 10
    Language: English
    In: Critical care (London, England), 2009, Vol.13 (1), p.R11-R11
    Description: One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6. Furthermore, there is an up regulation of transcription factors such as nuclear factor (NF) kappaB. It has previously been shown that clonidine is able to significantly reduce pro-inflammatory cytokines in surgical patients. We therefore hypothesise that the clinically used central alpha-2 agonist clonidine has the ability to improve survival in experimental sepsis by inhibiting the sympathetic tone and consequently inhibiting the pro-inflammatory cytokine release. To investigate this therapeutic potential of clonidine in a prospective randomised laboratory investigation we used a murine model of caecal ligation and puncture (CLP) induced sepsis. Animals receiving pre-emptive injections were treated with either clonidine (5 microg/kg) or dexmedetomidine (40 microg/kg) 12 and 1 hours before the operation, as well as 1, 6 and 12 hours afterwards. Another group of animals only received clonidine (5 microg/kg) 1, 6 and 12 hours after the operation, while the pre-emptive injections were normal saline. The control groups received solvent injections at the respective time points. Pre-emptive administration of a central sympatholytic significantly reduced mortality (clonidine: p = 0.015; dexmedetomidine: p = 0.029), although postoperative administration of clonidine failed to significantly prolong survival. Furthermore pre-emptive administration of clonidine significantly attenuated the cytokine response after CLP-induced sepsis (mIL-1beta: p = 0.017; mIL-6: p 〈 0.0001; mTNF-alpha: p 〈 0.0001), preserved blood pressure control (p = 0.024) and down-regulated the binding activity of NF-kappaB. There were no changes in the pro-inflammatory cytokine response when peripheral blood was incubated with lipopolysaccharide alone compared with incubation with clonidine (10-4 M) plus LPS (p 〉 0.05). Our results demonstrate that the pre-emptive administration of either clonidine or dexmedetomidine have the ability to successfully improve survival in experimental sepsis. Furthermore, there seems to be a connection between the central muscarinic network and the vagal cholinergic response. By down-regulating pro-inflammatory mediators sympatholytics may be a useful adjunct sedative in patients with a high risk for developing sepsis.
    Subject(s): Survival Rate - trends ; Receptors, Cholinergic - metabolism ; Humans ; Mice, Inbred C57BL ; Receptors, Muscarinic - metabolism ; Sepsis - mortality ; Sepsis - drug therapy ; Animals ; Sympatholytics - administration & dosage ; Female ; Mice ; Sepsis - blood ; Disease Models, Animal ; Dexmedetomidine ; Sepsis ; Clonidine ; Dosage and administration ; Diagnosis ; Research ; Drug therapy ; Risk factors ; Index Medicus
    ISSN: 1364-8535
    E-ISSN: 1466-609X
    Source: BioMedCentral Open Access
    Source: PubMed Central
    Source: Directory of Open Access Journals
    Source: Alma/SFX Local Collection
    Source: © ProQuest LLC All rights reserved〈img src="https://exlibris-pub.s3.amazonaws.com/PQ_Logo.jpg" style="vertical-align:middle;margin-left:7px"〉
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