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  • 1
    Language: English
    In: Dental materials, 2015, Vol.31 (12), p.1453-1459
    Description: Highlights • This study evaluates the flexural strength, Weibull modulus, and fracture mode of ceramic structures obtained by the CAD-on technique. • This study tested the hypothesis that trilayer and monolithic structures show similar values for the evaluated properties. • Monolithic and trilayer specimens showed similar mean flexural strengths, characteristic strengths and Weibull moduli. • Considering the CAD-on technique, the trilayer structures showed greater fracture toughness than the monolithic zirconia specimens.
    Subject(s): Advanced Basic Science ; Dentistry ; Dental ceramics ; Fractography ; Flexural strength ; Monolithic and trilayer structures ; Microscopy, Electron, Scanning ; Pliability ; Reproducibility of Results ; Ceramics - chemistry ; Dental Porcelain - chemistry ; Surface Properties ; Zirconium - chemistry ; Dental Stress Analysis ; Stress, Mechanical ; Materials Testing ; Elastic Modulus ; Computer-Aided Design ; Zirconium ; Methods ; Computer-aided design
    ISSN: 0109-5641
    E-ISSN: 1879-0097
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 2
    Language: English
    In: Scientific reports, 2016-11-28, Vol.6 (1), p.37131-37131
    Description: Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory syndrome (SARS) coronavirus (CoV) contains internal domains called fusion peptides (FP) that play essential roles in virus entry. Although membrane fusion has been broadly studied, there are still major gaps in the molecular details of lipid rearrangements in the bilayer during fusion peptide-membrane interactions. Here we employed differential scanning calorimetry (DSC) and electron spin resonance (ESR) to gather information on the membrane fusion mechanism promoted by two putative SARS FPs. DSC data showed the peptides strongly perturb the structural integrity of anionic vesicles and support the hypothesis that the peptides generate opposing curvature stresses on phosphatidylethanolamine membranes. ESR showed that both FPs increase lipid packing and head group ordering as well as reduce the intramembrane water content for anionic membranes. Therefore, bending moment in the bilayer could be generated, promoting negative curvature. The significance of the ordering effect, membrane dehydration, changes in the curvature properties and the possible role of negatively charged phospholipids in helping to overcome the high kinetic barrier involved in the different stages of the SARS-CoV-mediated membrane fusion are discussed.
    Subject(s): Cell Membrane - chemistry ; Thermodynamics ; Electron Spin Resonance Spectroscopy ; Membrane Fusion ; Peptides - chemistry ; Viral Fusion Proteins - chemistry ; Calorimetry, Differential Scanning ; SARS Virus - chemistry ; Virus Internalization ; Membrane fusion ; Differential scanning calorimetry ; Phosphatidylethanolamine ; Peptides ; Electron spin resonance ; Severe acute respiratory syndrome ; Mechanical properties ; Glycoproteins ; Phospholipids ; Coronaviruses ; Dehydration ; Packing ; Water content ; Spike glycoprotein ; Index Medicus
    ISSN: 2045-2322
    E-ISSN: 2045-2322
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: PubMed Central
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  • 3
    Language: English
    In: Leukemia, 2007-04, Vol.21 (4), p.838-842
    Subject(s): Cell Division - genetics ; Bortezomib ; Lymphoma, Large B-Cell, Diffuse - pathology ; Apoptosis - drug effects ; Humans ; Enzyme Inhibitors - pharmacology ; Proteasome Endopeptidase Complex ; G2 Phase - drug effects ; Cell Line, Tumor ; Antineoplastic Agents - pharmacology ; Cell Cycle - drug effects ; Proteasome Inhibitors ; Pyrazines - pharmacology ; Boronic Acids - pharmacology ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 4
    Language: English
    In: Dental materials, 2016, Vol.32 (5), p.624-630
    Description: Highlights • This study evaluates the reliability of ceramic fixed partial dentures prepared using the CAD-on technology. • This study tested the hypothesis that cyclic fatigue influences the reliability and failure behavior of the FPDs when compared to fast fracture testing. • Porcelain chipping was the predominant (60%) mode of failure for FPDs tested in fast fracture and connector failure was predominant (67%) under fatigue. • When chipping and connector fracture data were analyzed separately, the β values were 7.9 and 2.9. • The test method (fast fracture or fatigue) significantly influenced the reliability of FPDs fabricated using the CAD-on technique, but it did not influence their failure behavior.
    Subject(s): Advanced Basic Science ; Dentistry ; Zirconia ; Dental ceramics ; Fatigue ; Lithium disilicate ; Step stress ; Dental Porcelain ; Reproducibility of Results ; Zirconium ; Dental Stress Analysis ; Stress, Mechanical ; Materials Testing ; Denture, Partial, Fixed ; Ceramics ; Computer-Aided Design ; Dental Restoration Failure ; Flat panel displays ; Analysis ; Computer-aided design
    ISSN: 0109-5641
    E-ISSN: 1879-0097
    Source: Backfile Package - All of Back Files EBS [ALLOFBCKF]
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  • 5
    Language: English
    In: International journal of legal medicine, 2019-05-01, Vol.133 (3), p.777-779
    Description: We analyzed 23 Y-STR haplotypes of 139 unrelated males from Central Argentine Patagonia. A total of 133 different haplotypes (127 singletons) were observed. Haplotype diversity was similar to that previously observed in other Argentine populations and matching probability showed a strong dependence on the sample size. AMOVA carried out with full haplotypes showed significant differences between different regions of the country. The multi-dimensional scaling plot showed Chubut sample in an intermediate position among Europe and other Patagonian populations. These results will contribute to increase the Y-chromosome haplotype reference database and constitute a useful tool for anthropological and forensic researches.
    Subject(s): Forensic Medicine ; 23 Y-STR ; Central Patagonia ; Medicine & Public Health ; Medical Law ; Medicine/Public Health, general ; Regional differences ; Genetic Variation ; Haplotypes ; Chromosomes, Human, Y ; Genetics, Population ; Argentina ; DNA Fingerprinting ; Humans ; Male ; Microsatellite Repeats ; Y chromosomes ; Populations ; Forensic engineering ; Dependence ; Index Medicus
    ISSN: 0937-9827
    E-ISSN: 1437-1596
    Source: Alma/SFX Local Collection
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  • 6
    Language: English
    In: Clinical oral investigations, 2017-11, Vol.21 (8), p.2509-2520
    Description: This paper aims to assess the whitening effectiveness and toxicity of tooth-bleaching protocols applied to enamel/dentin disks simulating mandibular incisors (ICs) and premolars (PMs).A 10% hydrogen peroxide (H2O2) gel was applied for 3 × 15, 1 × 15, or 1 × 5 min to enamel/dentin disks simulating mandibular ICs and PMs, and the trans-enamel and trans-dentinal diffusion products were applied to human dental pulp cells (1 h). Professional therapy (35% H2O2—3 × 15 min) was used as positive control, and non-bleached samples were used as negative control. Cell viability and morphology, oxidative stress generation, and odontoblastic marker expression were assessed. The H2O2 diffusion and enamel color change (ΔE) were also analyzed.The 10% H2O2 gel induced significant cell viability reduction only when applied 3 × 15 min, with the intensity of oxidative stress and down-regulation of odontoblastic markers being higher in the IC group. The other experimental bleaching protocols caused slight alterations regarding the cell parameters evaluated, with intensity being related to enamel/dentin thickness. These effects were also correlated with higher H2O2 diffusion in the IC group. ΔE values similar as positive control were found for the 10% 3 × 15 and 1 × 15 protocols on IC group, after 4 and 6 sessions.Application of a 10% H2O2 bleaching gel for 15 or 45 min to thin dental substrate significantly minimizes cell toxicity in comparison with highly concentrated gels associated with similar esthetic outcomes by increasing the number of bleaching sessions.Bleaching gels with 10% H2O2 applied in small teeth for short periods may be an interesting alternative to obtain whitening effectiveness without causing toxicity to pulp cells, which may be able to reduce the tooth hypersensitivity claimed by patients.
    Subject(s): Tooth bleaching ; Cytotoxicity ; Dentistry ; Cell differentiation ; Dental pulp ; Analysis ; Hydrogen peroxide ; Dentin ; Oxidative stress ; Mandible ; Gels ; Toxicity ; Enamel ; Hypersensitivity ; Teeth ; Cytology ; Cosmetic dentistry ; Dental enamel ; Bleaching ; Premolars ; Incisors ; Diffusion
    ISSN: 1432-6981
    E-ISSN: 1436-3771
    Source: Alma/SFX Local Collection
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  • 7
    Language: English
    In: Ultrasound in obstetrics & gynecology, 2020-10, Vol.56, p.336-336
    ISSN: 0960-7692
    E-ISSN: 1469-0705
    Source: Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
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  • 8
    Language: English
    In: Leukemia, 2014-02, Vol.28 (2), p.278-288
    Description: T-acute lymphoblastic leukemia (T-ALL) is characterized by several genetic alterations and poor prognosis in about 20-25% of patients. Notably, about 60% of T-ALL shows increased Notch1 activity, due to activating NOTCH1 mutations or alterations in the FBW7 gene, which confer to the cell a strong growth advantage. Therapeutic targeting of Notch signaling could be clinically relevant, especially for chemotherapy refractory patients. This study investigated the therapeutic efficacy of a novel anti-Notch1 monoclonal antibody by taking advantage of a collection of pediatric T-ALL engrafted systemically in NOD/SCID mice and genetically characterized with respect to NOTCH1/FBW7 mutations. Anti-Notch1 treatment greatly delayed engraftment of T-ALL cells bearing Notch1 mutations, including samples derived from poor responders or relapsed patients. Notably, the therapeutic efficacy of anti-Notch1 therapy was significantly enhanced in combination with dexamethasone. Anti-Notch1 treatment increased T-ALL cell apoptosis, decreased proliferation and caused strong inhibitory effects on Notch-target genes expression along with complex modulations of gene expression profiles involving cell metabolism. Serial transplantation experiments suggested that anti-Notch1 therapy could compromise leukemia-initiating cell functions. These results show therapeutic efficacy of Notch1 blockade for T-ALL, highlight the potential of combination with dexamethasone and identify surrogate biomarkers of the therapeutic response.
    Subject(s): Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology ; Neoplastic Stem Cells - drug effects ; Humans ; Child, Preschool ; Antineoplastic Agents - administration & dosage ; Molecular Targeted Therapy ; Dexamethasone - pharmacology ; Neoplastic Stem Cells - metabolism ; Antineoplastic Agents - pharmacology ; Child ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Disease Models, Animal ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Dexamethasone - administration & dosage ; Antibodies, Monoclonal - pharmacology ; Gene Expression Regulation, Leukemic - drug effects ; Receptor, Notch1 - metabolism ; Drug Synergism ; Xenograft Model Antitumor Assays ; Animals ; Tumor Burden - drug effects ; Antibodies, Monoclonal - administration & dosage ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Adolescent ; Mice ; Receptor, Notch1 - antagonists & inhibitors ; Neoplasm Staging ; Viral antibodies ; Care and treatment ; Usage ; Lymphocytic leukemia ; Gene mutations ; Patient outcomes ; Xenotransplantation ; Antibodies ; Physiological aspects ; Diagnosis ; Research ; Health aspects ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 9
    Language: English
    In: Leukemia, 2008-04, Vol.22 (4), p.771-782
    Description: Detection of minimal residual disease (MRD) is the most sensitive method to evaluate treatment response and one of the strongest predictors of outcome in childhood acute lymphoblastic leukemia (ALL). The 10-year update on the I-BFM-SG MRD study 91 demonstrates stable results (event-free survival), that is, standard risk group (MRD-SR) 93%, intermediate risk group (MRD-IR) 74%, and high risk group (MRD-HR) 16%. In multicenter trial AIEOP-BFM ALL 2000, patients were stratified by MRD detection using quantitative PCR after induction (TP1) and consolidation treatment (TP2). From 1 July 2000 to 31 October 2004, PCR target identification was performed in 3341 patients: 2365 (71%) patients had two or more sensitive targets (〈 or =10(-4)), 671 (20%) patients revealed only one sensitive target, 217 (6%) patients had targets with lower sensitivity, and 88 (3%) patients had no targets. MRD-based risk group assignment was feasible in 2594 (78%) patients: 40% were classified as MRD-SR (two sensitive targets, MRD negativity at both time points), 8% as MRD-HR (MRD 〉 or =10(-3) at TP2), and 52% as MRD-IR. The remaining 823 patients were stratified according to clinical risk features: HR (n=108) and IR (n=715). In conclusion, MRD-PCR-based stratification using stringent criteria is feasible in almost 80% of patients in an international multicenter trial.
    Subject(s): Hematologic and hematopoietic diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Biological and medical sciences ; Medical sciences ; Genes, Immunoglobulin - genetics ; Risk Assessment ; Gene Rearrangement, T-Lymphocyte ; Humans ; Child, Preschool ; Infant ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Neoplasm, Residual ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Gene Rearrangement ; Adolescent ; Polymerase Chain Reaction ; Child ; Polymerase chain reaction ; Care and treatment ; Usage ; Antigen receptors, T cell ; Receptors ; Genetic aspects ; Acute lymphocytic leukemia ; Diagnosis ; Research ; T cells ; Health aspects ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Academic Search Ultimate
    Source: Alma/SFX Local Collection
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  • 10
    Language: English
    In: Leukemia, 2017-02, Vol.31 (2), p.498-501
    Subject(s): Lymphoma, Large-Cell, Anaplastic - classification ; Protein-Tyrosine Kinases - metabolism ; Child ; Humans ; Lymphoma, Large-Cell, Anaplastic - metabolism ; Index Medicus
    ISSN: 0887-6924
    E-ISSN: 1476-5551
    Source: Nature Open Access
    Source: Alma/SFX Local Collection
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