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  • 1
    Language: English
    In: Journal of Neurology, Neurosurgery & Psychiatry, 18 June 2011, Vol.82(6), p.681
    Description: A 29-year-old previously healthy man presented with a diarrhoeal illness, headache and malaise while in South Africa where he had been living for 6 months. Two weeks later, he developed diplopia and incoordination.
    Subject(s): Mri ; Infectious Diseases ; Ino ; Rickettsia ; Neuro-Ophthalmology
    ISSN: 0022-3050
    ISSN: 00223050
    E-ISSN: 1468-330X
    E-ISSN: 1468330X
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  • 2
    Language: English
    In: Journal of Neurology, Neurosurgery & Psychiatry, 20 December 2017, Vol.88(Suppl 1), p.A22
    Description: Focal epilepsy is the most frequent form of epilepsy in adults. Several pharmacogenomic studies have already interrogated factors associated with treatment response in newly diagnosed epilepsy, but there are no large scale GWAS in newly diagnosed focal epilepsy. Here we report results of a GWAS performed for an early remission after application of the first well tolerated anticonvulsant.
    Subject(s): Genomes ; Epilepsy ; Studies;
    ISSN: 0022-3050
    ISSN: 00223050
    E-ISSN: 1468-330X
    E-ISSN: 1468330X
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  • 3
    Language: English
    In: Medicina, 12/2011, Vol.47(12), p.96
    Description: BACKGROUND AND OBJECTIVE: Serological evidence of infection with Chlamydia pneumoniae has been associated with cardiovascular diseases, but the relationship with stroke and its risk factors remains not completely understood. The aim of this study was to determine whether serological evidence of infection with Chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes.MATERIAL AND METHODS: Confirmed stroke cases (n=102) were compared with gender- and age-matched control patients (n=48). The patients with stroke were divided into 3 groups according to the TOAST criteria: atherothrombotic (n=36), cardioembolic (n=47), and of undetermined etiology (n=19). Plasma levels of IgG antibodies to Chlamydia pneumoniae were measured by enzyme-linked immunosorbent assay.RESULTS: There was a significant association between seropositivity to Chlamydia pneumoniae and stroke. Anti-Chlamydia pneumoniae IgG antibodies were detected in 64 case patients (62.7%) and 17 control patients (35.4%) (χ(2)=9.8; df=1; P=0.002). IgG seropositivity to Chlamydia pneumoniae was linked to all the analyzed etiological subtypes of stroke.CONCLUSION: This study showed that IgG seropositivity to Chlamydia pneumoniae was associated with stroke and all the analyzed etiological subtypes of stroke.
    Subject(s): Medicine;
    ISSN: Medicina
    E-ISSN: 1010-660X
    E-ISSN: 16489144
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  • 4
    Language: English
    In: Medicina (Kaunas, Lithuania), 2011, Vol.47(12), pp.657-60
    Description: Serological evidence of infection with Chlamydia pneumoniae has been associated with cardiovascular diseases, but the relationship with stroke and its risk factors remains not completely understood. The aim of this study was to determine whether serological evidence of infection with Chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes. Confirmed stroke cases (n=102) were compared with gender- and age-matched control patients (n=48). The patients with stroke were divided into 3 groups according to the TOAST criteria: atherothrombotic (n=36), cardioembolic (n=47), and of undetermined etiology (n=19). Plasma levels of IgG antibodies to Chlamydia pneumoniae were measured by enzyme-linked immunosorbent assay. There was a significant association between seropositivity to Chlamydia pneumoniae and stroke. Anti-Chlamydia pneumoniae IgG antibodies were detected in 64 case patients (62.7%) and 17 control patients (35.4%) (χ(2)=9.8; df=1; P=0.002). IgG seropositivity to Chlamydia pneumoniae was linked to all the analyzed etiological subtypes of stroke. This study showed that IgG seropositivity to Chlamydia pneumoniae was associated with stroke and all the analyzed etiological subtypes of stroke.
    Subject(s): Antibodies, Bacterial -- Blood ; Chlamydophila Infections -- Blood ; Chlamydophila Pneumoniae -- Isolation & Purification ; Immunoglobulin G -- Blood ; Stroke -- Blood
    ISSN: 1010-660X
    E-ISSN: 1648-9144
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 5
    Language: English
    In: Journal of neurology, neurosurgery, and psychiatry, June 2011, Vol.82(6), pp.681
    Subject(s): Ophthalmoplegia -- Complications ; Rickettsia Infections -- Complications ; Tick-Borne Diseases -- Complications
    ISSN: 0022-3050
    E-ISSN: 1468-330X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 6
    In: Epilepsia, October 2017, Vol.58(10), pp.1734-1741
    Description: Byline: Ganna Androsova, Roland Krause, Mojgansadat Borghei, Merel Wassenaar, Pauls Auce,Andreja Avbersek, Felicitas Becker, Bianca Berghuis, Ellen Campbell, Antonietta Coppola, Ben Francis, Stefan Wolking, Gianpiero L. Cavalleri, John Craig, Norman Delanty, Bobby P. C. Koeleman, Wolfram S. Kunz, Holger Lerche, Anthony G. Marson,Josemir W. Sander, Graeme J. Sills,Pasquale Striano, Federico Zara, Sanjay M. Sisodiya, Chantal Depondt,, Martin J. Brodie, Krishna Chinthapalli, Gerrit-Jan Haan, Colin Doherty, Larus J. Gudmundsson, Sinead Heavin, Andres Ingason, Michael Johnson, Clare Kennedy, Martin Krenn, Mark McCormack, Terence J. O'Brien, Massimo Pandolfo, Ekaterina Pataraia, Slave Petrovski, Sarah Rau, Narek Sargsyan, Lisa Slattery, Kari Stefansson, William Stern, Anna Tostevin, Joseph Willis, Fritz Zimprich Keywords: Retention; Efficacy; Adverse drug reactions; Drug response; Seizure freedom Summary Objective Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) treatment. Comparative AED effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with MTLE-HS. Methods Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12-month seizure freedom, and adverse drug reaction (ADR) rates for the 10 most commonly used AEDs in patients with MTLE-HS. Results Seven hundred sixty-seven patients with a total of 3,249 AED trials were included. The highest 12-month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve-month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for AEDs that were prescribed as initial treatment and lowest for AEDs that were used in a third or higher instance. ADRs were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported ADRs were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia. Significance Our results did not demonstrate any clear advantage of newer versus older AEDs. Our results provide useful insights into AED retention, efficacy, and ADR rates in patients with MTLE-HS. Article Note: EpiPGX Consortium Contributors are listed in the Appendix. Authors contributed equally. CAPTION(S): Table S1. Breakdown of subjects by centers. Figure S1. Distribution of AED start dates. Figure S2. AED treatment duration. Table S2. Order of AED use. Figure S3. Frequencies of patients' age distribution. Table S3. Reasons for AED discontinuation.
    Subject(s): Retention ; Efficacy ; Adverse Drug Reactions ; Drug Response ; Seizure Freedom
    ISSN: 0013-9580
    E-ISSN: 1528-1167
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  • 7
    In: Acta Chirurgica Latviensis, 01/1/2010, Vol.10(2)
    Description: Introduction. Stroke is the second most common cause of death worldwide and one of the major causes of long-term disability. Carotid artery stenosis is an independent risk factor for ischemic stroke and related forms of atherosclerotic vascular disease. Aim of the Study was to examine plasma homocysteine (tHcy) levels in the stroke patient's group with significant carotid artery stenosis, to determine hyperhomocysteinemia correlation with degree of carotid artery stenosis. Materials and methods. This study was prospective and all patients (n=102) included in the study were hospitalized in Pauls Stradins Clinical University hospital in Clinic of Neurology with diagnosis of acute ischemic stroke. In the group of significant carotidal stenosis we included 48 patients with various degree of stenosis ranging from 50% to total occlusion. Evaluations of stenosis of extracranial carotid arteries were done by duplex ultrasonography method. The blood of these patients was tested for homocysteine level by ELISA (IMMULITE 2000). Results. Study did not demonstrated statistically significant difference between levels of tHcy in all groups. Mean homocysteine level was not significantly higher in the symptomatic carotid stenosis patient's group. Also there were no significant differences between levels of homocysteine in patient group with different degree of stenosis. Conclusions. We found no meaningful association between a high tHcy level and extent of carotid stenosis.
    Subject(s): Hyperhomocysteinemia ; Stroke ; Carotid Stenosis;
    ISSN: 1407-981X
    E-ISSN: 21995737
    Source: CrossRef
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  • 8
    In: Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 01/1/2010, Vol.64(3-4), pp.133-136
    Description: Cytomegalovirus chronic infection as a risk factor for stroke: a prospective studyStroke is the second most common cause of death in the world and a major cause of long-term disability. Chronic infection is an independent risk factor for ischemic stroke and related forms of atherosclerotic vascular disease. The aim of our study was to compare the plasma Cytomegalovirus (CMV) immunoglobulin G antibody level in a patient and control group, and to determine the association of CMV chronic infection with ischemic stroke, and with stroke subtype. The present study does not present a cogent demonstration that cytomegalovirus chronic infection is a risk factor of stroke. Further studies are necessary to clarify the effective prophylactic measures to determine other significant risk factors for stroke.Citomegalovīruss kā cerebrāla infarkta riska faktors: prospektīvs pētījumsCitomegalovīruss (CMV) ir zināms arī kā cilvēka herpesvīruss 5 (HHV5), tas pieder pie beta herpesvīrusu dzimtas un ir sastopams visos geogrāfiskajos regionos un sociālekonomiskajās grupās. Ar CMV inficēti 50-80% populācijas un tās seroprevalence tieši korelē ar vecumu. Nonākot asinīs, CMV reproducējās leikocītos un monocitāto makrofāgu sistēmas šūnās vai persistē limfoīdos audos. Makrofāgs, kas ir inficēts ar vīrusu, sāk stimulēt MCR-1 ekspresiju, līdz ar to CMV var nosaukt par starpnieku MCR-1 ekspresijas procesā - tas ir mehānisms, kas veicina endotēlija bojājumu. Hroniska CMV infekcija varētu būt viens no iespējamajiem iesaistītajiem faktoriem, kas izraisa endotēlija disfunkciju un iekaisumu, stimulējot aterosklerozi. Mūsu pētījuma mērķis bija izpētīt citomegalovīrusa hronisko infekciju kā cerebrāla infarkta riska faktoru, tā saistību ar insulta apakštipu un citiem riska faktoriem. Pētījums veikts Paula Stradiņa Klīniskajā universitātes slimnīcā Neirologijas nodaļā, un tajā piedalījās 150 cilvēki. Pētījumā pamata grupā bija iesaistīti 102 pacienti, no tiem 61 vīrietis un 41 sieviete vecumā no 42 līdz 89 gadiem, vidējais vecums 65,8 ± 10,9 gadi. Kontroles grupā bija 48 cilvēki, no tiem 26 vīrieši un 22 sievietes vecumā no 42 līdz 82 gadiem, vidējais vecums 64,3 ± 11,8 gadi. Pacientu grupai un kontroles grupai bija noteikts imūnglobulīna G (Ig G) CMV līmenis asinīs. Pozitīvas IgG antivielas pret CMV tika atrastas 95 pacientiem no 102 (92,2%) slimnieku grupā un 45 no 48 kontrolgrupas dalībniekiem. Rezultāti starp grupām statistiski ticami neatšķīrās (χ2 = 0.02; P 〉 0,05). Vidējais CMV antivielu līmenis asins serumā pacientu grupā bija nedaudz augstāks nekā kontrolgrupai, bet rezultāti statistiski ticami neatšķīrās (t = 1,274; P 〉 0,05). Analizējot pozitīvas antivielas pret CMV statistiski ticama korelācija bija atrasta ar iekaisuma radītāju - leikocitozi (r = 0,282; P P P
    Subject(s): Sciences (General);
    ISSN: 1407-009X
    E-ISSN: 2255890X
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  • 9
    In: Neurology, 2018, Vol.90(4), pp.e332-e341
    Description: OBJECTIVE: To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. METHODS: We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. RESULTS: We report an association between a rare variant in the complement factor H–related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 × 10; odds ratio [95% confidence interval] 7 [3.2–16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. CONCLUSIONS: The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H–related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients.
    Subject(s): 53 ; 60 ; 61 ; 95 ; Article;
    ISBN: 0004277995000
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 10
    In: Epilepsia, April 2020, Vol.61(4), pp.657-666
    Description: Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified. We aimed to identify the role of rare genetic variants in drug resistance for three common ASMs: levetiracetam (LEV), lamotrigine (LTG), and valproic acid (VPA). A cohort of 1622 individuals of European descent with epilepsy was deeply phenotyped and underwent whole exome sequencing (WES), comprising 575 taking LEV, 826 LTG, and 782 VPA. We performed gene- and gene set-based collapsing analyses comparing responders and nonresponders to the three drugs to determine the burden of different categories of rare genetic variants. We observed a marginally significant enrichment of rare missense, truncating, and splice region variants in individuals who were resistant to VPA compared to VPA responders for genes involved in VPA pharmacokinetics. We also found a borderline significant enrichment of truncating and splice region variants in the synaptic vesicle glycoprotein (SV2) gene family in nonresponders compared to responders to LEV. We did not see any significant enrichment using a gene-based approach. In our pharmacogenetic study, we identified a slightly increased burden of damaging variants in gene groups related to drug kinetics or targeting in individuals presenting with drug resistance to VPA or LEV. Such variants could thus determine a genetic contribution to drug resistance.
    Subject(s): Burden Analysis ; Lamotrigine ; Levetiracetam ; Pharmacogenomics ; Rare Variants ; Valproic Acid
    ISSN: 0013-9580
    E-ISSN: 1528-1167
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